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Judgment night soundtrack cd6/26/2023 ![]() ![]() (Alas, the 1993 gritty-crime-thriller spoof Loaded Weapon 1, which starred Emilio Estevez and Samuel L. Lotta cornball B-movies I don’t believe existed even if I saw them in the theater at the time. Lotta starry-eyed knuckleheads such as myself buying those CDs for full price. Quick summary of the ’90s: lotta alt-rock bands. (No offense to Machines of Loving Grace.) I am mentally headbanging along to the Rollins Band’s “Ghostrider” as I type this, and it makes me want to throw my laptop at the ceiling. In fact, let me elaborate: In 1994 I could recite for you the entire 14-track Crow soundtrack track list, from the bands I already loved (the Cure, Nine Inch Nails, Rage Against the Machine, Stone Temple Pilots) to the bands I’d never heard of and never listened to again. Few of these records tend to show up on Greatest Movie Soundtracks of All Time Lists, but all of them were absolutely essential to an uncommonly perceptive and charismatic ’90s teenager such as myself. I come before you today to praise the ’90s junk-drawer alt-rock soundtrack, a wildly profitable and mostly prestige-free cesspool of randos deployed randomly to promote everything from Godzilla to Reality Bites to Empire Records to The Crow to Beavis and Butt-head Do America to Mallrats to Lost Highway to (personal favorite) Angus to The Saint to Spawn. ![]() The 50 Best Movie Soundtracks of the Past 50 Years An elaborate ruse concocted for the sole purpose of gifting the world with the Judgment Night soundtrack, which is real, and yes indeed spectacular, and world-famous for its delightful conceit of pairing rowdy rock bands with even rowdier rappers, a somewhat revolutionary idea in 1993 that produced unholy one-song unions that remain hilariously incongruous in 2021. The “Swingin’ on the Flippity Flop” of cinema. Yeah, so where do these friends of yours even claim to have seen the feature film Judgment Night? Projected onto the side of a dumpster out behind a multiplex? Is this a link to the legit Judgment Night trailer or to a poorly synced clip of Crucial Taunt playing “Ballroom Blitz” near the end of the Wayne’s World movie? Who can say? I can. Is Judgment Night a real movie? Have you ever met anybody in your life who even claims to have seen the gritty 1993 replacement-level crime thriller Judgment Night, directed by Stephen Hopkins and starring Emilio Estevez, Cuba Gooding Jr., Denis Leary, Jeremy Piven, and Stephen Dorff? Real quick, can I share with you this paragraph from Stephen Hopkins’s Wikipedia page? Before that film examines the man who forever changed the way music and film interact with his work on Saturday Night Fever, The Ringer will spend the day celebrating the world of movie soundtracks that he so heavily influenced. Saturday Night, on the legendary producer Robert Stigwood. Questions about the show? Have album recommendations? Just want to say hi? We’d love to hear from you! Contact the show on Twitter, Roach Koach on Facebook, Roach Koach on Instagram, or send an email to RoachKoachPodcast at Gmail.On Thursday, Ringer Films will debut the latest installment of its HBO Music Box series, Mr. Facebook, Twitter, Instagram, let them know you’re a Roach Ryder for Life! Rate and review Roach Koach on iTunes! We’d appreciate it! Take a moment to like Roach Roach on Facebook. Thank you so much for listening! Please take a moment to share Roach Koach on your social media. ![]() Then we dive into the Judgment Night soundtrack(13:00), learn of Matt’s deep relationship with this album, discuss the critical ideal of rap rock, speak on the creation of the album, and discuss whether if is a Nu-Metal Papa or deserves a place in the Nu-Metal Canon. Along with that we do Who’s Tweeting and Who’s Instagramming(1:27), discuss some Limp Bizkit news, American Head Charge feedback, and listener love for Funky Ken. Here it is, the start of Compilation Month! This week Roach Roach listens to influential Judgment Night Soundtrack.
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Php image resize on upload6/26/2023 ![]() Most Popular Pages Baby Name Generator U.S. 2 Free Linux Admin Books Free Linux Books for Programmers Free Books for Linux on the Desktop Free PHP Books Free JavaScript Books Free Java Books - Advanced Free Java Books - Basic Free Perl Books Free Python Books Quote of the Day (PHP) Debugging Part 2 How to Test Google Ads The pnmscale programs are provided in the libgr-progs library package.īoth of these packages are available as RPMs for RedHat-compatible systems and can be found at your local RPM Repository Once the image upload is completed, then the PHP code will show the preview of the uploaded image. The PHP moveuploadedfile function moves the uploaded file to the specified target. The djpeg and cjpeg programs are provided in the libjpeg library package. PHP Image Upload Code This is the usual f ile upload code in PHP that is very familiar to us as we have seen in many file upload examples. Is_uploaded_file() Handling file uploads (a simple example) On php.net, there are User Contributed Notes for all PHP fuctions. So a slash at the front is much different than a slash ![]() Pay attention to file locations and paths.In other words, imagecopyresized () will take a rectangular area from srcimage of width srcwidth and height srcheight at position ( srcx, srcy) and place it in a. dstimage is the destination image, srcimage is the source image identifier. Make sure your web server has write access to the upload directory imagecopyresized () copies a rectangular portion of one image to another image.For example, "EMPID.jpg" whereĮMPID is the unique id of the employee's record. It would be better to not use the filename submitted but instead use a unique id.UNIX does not like filenames with spaces, though it's fine in Windows and Mac.Such asĬhecking the file extension, handling where to copy the file, and changing the upload filename.ĭownload the complete Script Source The directory this script runs in (or the upload directory) must be writable by the server There are a few little things added to complete the script. The above functions are just the basics of the script. System("pnmscale -xy 250 200 $tmpimg | cjpeg -smoo 10 -qual 50 >$newfile") If ($ext = "jpg") /*= scale image using pnmscale and output using cjpeg =*/ $newfile = "$uploaddir/scaled.jpg" /*= CONVERT IMAGE TO PNM =*/ If is_uploaded_file returns TRUE, copy the file from its temp location to where you want We do this with theĭetail about this function is at the PHP.net site. NOTE: imgfile is the name given on the formīefore copying the file, we check that a malicious user is not trying to abuse the script by trying to work on files it should PHP uploads the file to a temp location on your server (defined in php.ini) It also includes the following: ![]() I'll do it all on the same page checking for the REQUEST_METHOD to know Next we need to process the uploaded information when it is submitted. " method="POST" enctype="multipart/form-data"> Set using a hidden field and for this example will set to 50,000 bytes (approx. Needs to be set to the maximum allowable file size (in bytes) for upload. Else, I'll leave it as it is.įirst we need to create the form to upload the image. The uploaded image only if it is larger than 250x200. djpeg, cjpeg and pnmscale UNIX utility programs (see below).PHP has the ability to upload files such as documents or images using the multipart/form-data protocol, but how do you use thisĪnd how do you resize the images after they are uploaded? Resize Images in PHP (With 4 Lines Of Code) original imagecreatefromjpeg(ORIGINAL.jpg) resized imagecreatetruecolor(NEW WIDTH, NEW HEIGHT). Used all available PSR (Autoload, CodeStyle, etc.) Reduced portions of code by putting them into. Whatever it is, you need to be able to upload images eImage - Image upload, resize and crop eImage it's a simple PHP Class to make Uploading and Editing Images even more easy A rewrite of a old Class (image) originally written by Mark Jackson (mjdigital) all credits of main idea goes to him :D. Here is my code.You created a cool contact directory and you want to allow people to upload their own photos or you want to createĪn image repository which you upload images and create thumbnails out of them. Right now I am stretching the image and it looks bad but it works. TinyPNG Compress Images Using PHP How To Increase Upload File Size Limit PHP Copy Image From URL To Server Find Location From IP Address In PHP Part 1 Find. Hey, I want to be able to have a 100x100 thumbnail of pictures I am uploading while cropping the image to maintain the ratio.
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![]() Basic abilities help with skill checks, saving throws, and attack rolls. Plays music or sings to boost allies or weaken enemies. Pack Rager: Gains bonuses when fighting near allies.Mad Dog: Has an Animal Companion but loses Uncanny Dodge.Invulnerable Rager: This subclass provides much more damage reduction and resistances at the cost of Uncanny Dodge and Danger Sense.Instinctual Warrior: Loses all Barbarian Proficiencies, including damage reduction, but gains Blind Fight and various Rage Powers.Beastkin Berserker: Gains the ability to transform into a creature when raging, but loses Fast Movement.Armored Hulk: Loses Danger Sense, but gains Resilience of Steel, providing bonuses for wearing heavy armor.They also have Uncanny Dodge, to evade incoming damage, and Danger Sense, gaining a bonus on Reflex saves and extra AC against attacks by traps. ![]() Doesn’t need to learn said spells.Įxpect the usual features of a Barbarian including the ability to Rage (increasing attack and health, but fatiguing the character afterward). White Mage: Can expend points to cast a spell with “Cure” in the name.Phantasmal Mage: Gains metamagic abilities, but sacrifices a late game ability.Nature Mage: Has the Druid’s spell list instead of the Arcanist’s spell list.Eldritch Font: Can spend energy from the font to make spells harder to resist and more likely to succeed.Brown-Fur Transmuter: Can empower and share transmutation spells.Can consume spells (akin to using them) to refill the Arcane Reservoir or refill it after a long rest. Uses spell points to make spells stronger or make the DC higher. Vivisectionist: Doesn’t throw bombs, gains the ability to Sneak Attack, but does gain access to “evil” abilities like feral mutations and nauseating flesh.Īrcanists are a more difficult class that features Spellcasting, Arcane Reservoirs, and Arcanist Exploits.Preservationist: Over time, the Preservationist can summon more powerful animals when throwing bombs.Metamorph: Rather than throw bombs, the Metamorph gains the ability to transform into various creatures like leopards, bears, and dragons.Incense Synthesizer: Utilizes bombs which explode into fogs that buff allies.Grenadier: The grenadier has a special perk that causes bombs not to affect allies.Chirurgeon: An alchemist that can also heal and remove some negative status effects like poison and blindness.All alchemists eventually gain Poison Immunity. Spell Extracts are spells in potion form. Mutagens are essentially potions which buff and debuff various abilities and stats based on which one you drink. Bombs are AOE ranged attacks with varying effects. Depending on which subclass you choose, you’ll change which ones you focus on. The Alchemist is all about brewing up potions, bombs, and mutagens. In this guide, we’ll summarize each Pathfinder: Wrath of the Righteous class and subclass so you can get a good picture of what they all do without needing to do a whole bunch of clicking and comparing. That’s why we’ve sat down and gone through them all for you. With 25 different starting classes, 161 subclasses, and 13 class evolutions you can change into mid-game, there are so many options it’s likely to take you at least an hour figuring out what they all do. There are always a ton of options, and the newest Pathfinder game, Wrath of the Righteous, is no exception. One of the hardest parts of a classic RPG like Pathfinder, Divinity, or Pillars of Eternity is choosing which class you’re going to play.
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Keepassx org safe6/26/2023 You can also review our KeePass Sync Guide to get your passwords onto your mobile device easily. Read our KeePass Password Safe instructions on how to create a database, create password entries, retrieve passwords, and configure the application securely. You can use these plugins for seamless integration with web browsers, import/export of passwords, and automatically backup your vault. You can extend your KeePass client to make using the password manager easier. Android KeePassDroid in Google Play store.Note: see the sync guide to quickly transfer your desktop passwords to your mobile device Note: If you do not have administrative rights on your system, please choose the 'Portable' version to download. There are many KeePass client derivatives based off of the original open-source code for all flavours of operating systems. KeePassX is a free and open-source password manager. The codebase for KeePass has been peer reviewed and tested by Cyber Security all around the world, and is considered the best password for anyone who needs to keep their secrets safe. KeePass is a free, open-source and most importantly, offline. While many competitors exist like LastPass or 1Password, these are all cloud-based, closed source password managers which cost a yearly subscription to access. KeePass Password Safe is the industry standard recommendation for all users. This simple change to your authentication habits will make your accounts nearly impossible to hack ( with the exception being, someone socially engineering you into giving away your password).Įven if someone gets their clickers on your password manager database file, they will not be able to open it without your password because the file is strongly encrypted with 256-bit AES standards. KeePass uses SHA-256 to hash the master key. Our recommended solution is a simple, but effective, Password Manager application.īy creating a single strong unique passphrase, you can quickly create a secure vault of long, randomized passwords for each site and service you use everyday. The database file is encrypted using the best and most secure encryption algorithms, which are AES and Twofish. Keeping track of your passwords can be hard, but having short, easy to guess passwords can be worse. Go beyond saving passwords with the best password manager Generate strong passwords and store them in a secure vault.
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Mario kart 7 rom .3ds6/26/2023 ![]() Green: added in the last update (see Changelog) Orange: fixed/modified in the last update (see Changelog) Red: removed in the last update (see Changelog) Note: The "root" of the SD card means you just have to paste your "boot.firm" directly in it and not in any folder/subfolder. zip archive you extracted before, pick the "boot.firm" and put it at the root of your SD card and remove any boot.firm if it's required. Installation of the boot.firm (if it's needed!): Note: The backgrounds need to stay with their default names: "TopBackground.bmp" and "BottomBackground.bmp" Note: If one of these folder doesn't exist on your SD card, create it. Put the ".3gx" file, the both ".bmp" files and the "snd" folder in your SD card following one of these paths (depending on the MK7 region you have):.Installation of the plugin.3gx, the backgrounds and the custom sounds: If you have the right version, no need to install the boot.firm file, just pick the plugin. Note: To check your current Luma Loader's version, press "L + Down + Select" in the HOME menu, you will see it on the bottom screen. Luma Loader v10.2.1 (latest version, recommended) This plugin contains codes for every modes of Mario Kart 7: Online mode, Local Play mode and Solo mode. The main idea of this plugin is to use cheat codes without compatibility issues. This is my first CTRPF plugin using C++ and it wouldn't have existed without the people who helped me by teaching me some tips about this language. 4 years after the release of the Darkflare's Online Plugin, and the releases of some NTR plugins, I've decided (4-5 months ago) to refresh the ways to hack Mario Kart 7.
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Illustrate definition6/26/2023 ![]() The final stage is to wind the paper onto large rolls./ Finally, the paper is wound onto large rolls.At this point the new paper is still wet, so it is passed between large heated rollers, which press out the remaining water and simultaneously dry the paper/…dry the paper at the same time. We illustrate our definitions by including quotations or simple examples.She has illustrated several children ’s books. to draw the pictures in a book, or to put pictures in a book. The process is illustrated in Figure 4.6. This causes the solid material to sink to the bottom, forming a layer of paper. to show something by using pictures, diagrams, lists of numbers, etc. By now you have progressed from the very informal definition of a. Illustrate definition, to furnish (a book, magazine, etc.) with drawings, pictures, or other artwork intended for explanation, elucidation, or adornment. 2.5.4 Use the epsilon-delta definition to prove the limit laws. 2.5.3 Describe the epsilon-delta definitions of one-sided limits and infinite limits. 2.5.2 Apply the epsilon-delta definition to find the limit of a function. As the pulp travels along the conveyor belt, the water drains away. 2.5.1 Describe the epsilon-delta definition of a limit.The next stage is to feed the pulp into the paper machine, where it is mixed with water and then poured onto a wire conveyor belt.…is bleached so that impurities can be removed. Find 69 ways to say ILLUSTRATE, along with antonyms, related words, and example sentences at, the world's most trusted free thesaurus. Once/ After the wood has been pulped, the pulp is bleached in order to remove impurities.Pulping breaks down the internal structure of the wood and enables/ allows the natural oils to be removed.Next/ Second, the wood chips are pulped, either using chemicals or in a pulping machine.First/ First of all, logs are delivered to a paper mill, where the bark is removed and the wood is cut into small chips.This diagram illustrates the process of paper-making./This diagram shows how paper is made.v clarify by giving an example of Synonyms. Language Bank process process Describing a process illustrate: 1 v depict with an illustration Type of: depict, picture, render, show show in, or as in, a picture v supply with illustrations illustrate a book with drawings Type of: adorn, beautify, decorate, embellish, grace, ornament make more attractive by adding ornament, colour, etc.
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Silverlight plugin crashed6/26/2023 ![]() R3228 Changes the download behavior for files that could execute code (exe, dll, bat, etc.). There are more plugin performance updates in this release, including fixing some videos that halt after 1 second ( r3123, Issue 115 ) and plugins causing the browser to become unresponsive ( r3323 ). We fixed the new crashes and 154.3 should be much more stable. Release 154.0 had a few browser crashes, including a crash on startup on tablet PCs running Windows Vista. You can learn more about the Dev channel and how to subscribe here: The Dev channel lets you test the latest fixes and get access to new features as they're being developed. Google Chrome 0.3.154.3 has been released to the Dev channel ONLY. Mark Larson, Google Chrome Program Manager Downloads that you never confirm are deleted when Google Chrome exits. ![]() Only after you click Save is the unconfirmed_*.download file converted to the real file name. Google Chrome asks you if you want to accept the download. These files are now downloaded to unconfirmed_*.download files. The download behavior for files that could run programs (exe, dll, bat, etc.) has changed.You can now add words to the spell check dictionary so they are not shown as misspelled (right click on a misspelled word and choose 'Add to dictionary.'). The spell checker works on text input fields and underlines misspelled words.Both options are always visible on the wrench menu. 'New window' always opens a new normal window. 'New incognito window' always opens a new window.Thanks to Szymon Piechowicz for the patch. The New tab, New window, and New incognito window options moved from the 'Control the current page' menu to the 'Customize and control Google Chrome' (wrench) menu.
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Surviving high school app download6/26/2023 ![]() The parties have different activities and games you can play. On the weekends, you have the choice to attend parties or stay at home and study. The word searches are not very difficult but add variety to a game that is otherwise dominated by making choices and decisions for your character. One task is in football practice, where you must select the words "toss" and "pass" to learn “special moves” for the games as shown below. Another mini game is a word search that you must do to complete certain tasks. The rival school is always trying to start fights and talk trash throughout the game. Especially when you consider that your dad will buy you a new car if you maintain a 3.0 GPA!Īnother mini game is football, which isn’t very much like real football as you can see here:įor example, you can’t select any plays on offense or defense you may only select how many yards each play is, which gets old after a couple of series.Įvery week, there is a football game and the final week there is a game against the rival school. Or you can choose to cut class with the popular kids, which will make you more popular but won't help your GPA one iota. If you do well on the quiz your GPA will go up. The app features various mini games, including quizzes like this: Some of the characters even sounded like my real friends.Īfter school, you have choices in which you can do including working out which helps your athleticism, since you have an opportunity to try out for the football team as a quarterback, studying which boosts your GPA, or watching TV which boosts social status. You can make friends as well as enemies depending upon the choices you make.Īll of the characters in the game are very realistic and behave a lot like real high school students. As soon as you arrive at school you'll be approached by all types of people including a girl you can flirt with and the star varsity quarterback. Regardless of your choices, you are a new student at the high school. Among other options you can choose from several different characters and select the classes you will take. When you launch the app for the first time you have many options for your simulated high school life and choices you make in the beginning influence the course your high school career will take throughout the game. This simulator/game was surprisingly realistic and more fun than I expected. Mac's 17-year old son and a high school junior. Everyone knows how tough it can be to balance your social life, sports, and academics, and it is just as challenging in this game. Have you ever wished you could relive your high school years but make different choices and do different things? Well now you can with the new app from Electronic Arts, Surviving High School, a simulator/game that allows you to make the kinds of decisions you would make as a high schooler. As a junior in high school I think he has a much better handle on what high school is like, how well this simulation/game emulates the real deal, and how much fun it is to play. This app: Contains direct links to the Internet Contains advertisements for EA and its partners Collects data through third party analytics technology (see Privacy & Cookie Policy for details).NOTE: While the Mac Observer content management system says that I wrote this review, it was mostly written by my 17-year old son Jacob. Meet other fans and even get inside news from the writers!ĬHAT WITH US: /survivinghighschoolīe the first to know! Get inside EA info on great deals, plus the latest game updates, tips & more…Ĭheck out more exciting games from EA like The Sims FreePlay, Need for Speed Most Wanted, and Theme Park!ĮA may retire online features and services after 30 days’ notice posted on Important Consumer Information. ![]()
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Istat pro mac download6/25/2023 ![]() Realtime listings of the sensors in your Mac, including temperatures, hard drive temperatures (where supported), fans, voltages, current and power. Detailed disk I/O in your menubar, displayed as a graph, a variety of different read and write indicators, or both. status monitoring and more detail for all your disks is only a click away. See used and free space for multiple disks in your menubar. Opening the menu shows a list of the apps using the most memory, and other useful info.Ī realtime graph to keep on top of what’s being sent and received for all network connections, including a bandwidth breakdown for the top 5 apps. Memory stats for your menubar as a pie chart, graph, percentage, bar or any combination of those things. ![]() Plus, GPU memory and processor usage on supported Macs, and the active GPU can be shown in the menubar. CPU usage can be tracked by individual cores or with all cores combined, to save menubar space. Realtime CPU graphs and a list of the top 5 CPU resource hogs. Our menubar and dropdown menus are now localised for Arabic, Catalan, Chinese (Simplified), Chinese (Traditional), Croatian, Czech, Danish, Dutch, Finnish, French, German, Greek, Hebrew, Hungarian, Italian, Japanese, Korean, Norwegian, Polish, Portuguese, Portuguese (Portugal), Romanian, Russian, Slovak, Spanish, Swedish, Thai, Turkish, and Ukrainian. Daylight is now indicated in the clock face (it even fades near sunrise and sunset). ![]() Improved GPU monitoring, including active GPU in menubar.Ī vastly improved time menu, with current time, sunrise, noon, sunset, dawn, dusk, sun azimuth, sun altitude, light map and more for over 120,000 cities. Wi-Fi stats, including channel, signal to noise ratio and many more. Upload and download activity is also shown per-app, making it far easier to track down the biggest bandwidth hogs.įar more detailed network information, including router address, subnet mask, DNS and MAC address. IStat Menus 5 features read and write disk activity on a per-app basis. Menubar graphs can now use dark backgrounds, improving legibility. iStat Menus 6 sports a completely new design - new menubar icons, new dropdown menus, and the app and icon itself have all been redesigned to be cleaner, clearer and more at home on Yosemite. Included are 8 menu extras that let you monitor every aspect of your system. IStat Menus lets you monitor your system right from the menubar. It is extremely configurable, and if you search, you'll find many screenshots of customized conky installations. It is also installable from the Software center or via apt-get. ![]() Gkrellm-radio - FM radio tuner for GKrellMĪnd here's a themes directory (the last time I installed it, this is the site I used to find a theme I liked): /gkrellm Gkrellm-mldonkey - mldonkey plugin for gkrellm2 Gkrellm-mailwatch - GKrellM plugin to watch mailboxes in multiple panels Gkrellm-leds - Keyboard LED monitor for GKrellM Gkrellm-ibam - Advanced battery monitor for laptops - gkrellm plugin Gkrellm-hdplop - A hard drive activity monitor GKrellM plugin Here's an extract: gkrellm-bfm - system load plugin for gkrellm with a duck You can see the easily installed plugins with apt-cache search gkrellm. You can install the basic application from the Software Center or via the command line, with apt-get install gkrellm, but there are numerous plugins and themes available. it works out of the box, but you will probably want to tinker a bit to get the look and the info you're after.
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Kevin renderman brain tumor6/25/2023 ![]() Systemic cancers most likely to metastasize to the CNS include lung cancer, melanoma, and breast cancer. It's a constant reminder how far he's come. Brain tumors are a diverse group of neoplasms arising from different cells within the central nervous system (CNS) or from systemic cancers that have metastasized to the CNS. The irony of it all is that every time Kevin takes the mound at Penn, he does it in the shadows of CHOP, where he had his procedure and all of his appointments. Looking back on it, you kind of get the perspective like I'm pretty lucky that I have what I have," Kevin said. "If my tumor was any different or malignant, there was really nothing they'd be able to do. He's made a full recovery and today, he's one of the best freshman on the University of Pennsylvania's baseball team. So the Monroeville, New Jersey native still lives with the tumor in his head. ![]() Thankfully, the tumor was benign, but it was also inoperable because of its location. "We had a perfectly healthy, happy kid playing baseball on a Sunday and by Friday, he was having brain surgery and hole drilled in the top of his head," Kevin's mother Debbie Eaise said. The 10-year-old boy immediately had brain surgery at Children's Hospital of Philadelphia. Within a week, doctors discovered a tumor. Nearly nine years ago, during a Vineland Little League game, he began seeing double. After leukemia, tumors of the brain and spine are the second most common form of cancer in children. PHILADELPHIA (WPVI) - University of Pennsylvania pitcher Kevin Eaise remembers the day his world was thrown into a panic in the blink of an eye. ![]() Jeff Skversky has more on Action News at 6 p.m. Learn more about brain cancer care at UConn Health.UPenn baseball player living with brain tumor hoping to help others. UConn Health will share additional details about the research, including information on eligibility requirements and how patients can participate, later this year. “UConn Health’s involvement in this very promising trial affirms our standing as a world-class institution for clinical care and research in neuro-oncology.” Ketan Bulsara, chief of UConn Health’s Division of Neurosurgery. Becker’s leadership, and it is also a tribute to the great multidisciplinary team that has been created through the Carole and Ray Neag Comprehensive Cancer Center and our Brain and Spine Institute,” says Dr. “To be selected as one of a handful of sites in the world for this trial is truly a tribute to Dr. The investigators believe the one-two punch of therapies may be able to generate “a potent and specific anti-tumor response” in patients with recurrent malignant glioblastoma, a type of aggressive and often fatal brain tumor. LUMINOS-101 is how Istari Oncology is branding this clinical trial. (Images provided by Istari Oncology, Inc.) The therapy used, known as PVSRIPO, is being studied in combination with the cancer immunotherapy pembrolizumab, with UConn Health among a select few sites for this phase of the clinical trial. ![]() This is truly a landmark trial for patients with recurrent glioblastomas.” Comparative brain scans show the difference in tumor size from before infusion to 25 months after infusion. “We are extremely honored to be one of only a few selected sites for the LUMINOS-101 trial. Kevin Becker, director of neuro-oncology and UConn Health’s primary investigator for this trial. “This is a tremendous example of the innovative trials we envision as we build our neuro-oncology program at UConn,” says Dr. Istari Oncology, Inc., the North Carolina-based biotechnology company sponsoring the research, has selected UConn Health as a site for this phase of the trial. It is also being studied across a range of cancers including melanoma, for which the FDA has granted “orphan drug status.” Food and Drug Administration for recurrent glioblastoma. PVSRIPO has been granted “breakthrough therapy designation” from the U.S. The rationale for studying these agents in combination is evidence that indicates these drugs work synergistically to activate the immune system to fight cancer. The therapy combines what researchers are calling PVSRIPO, a viral immunotherapy based on the polio vaccine, with pembrolizumab, an immunotherapy drug shown to be effective in treating many other types of cancers, marketed under the brand name Keytruda. ‘This is a tremendous example of the innovative trials we envision as we build our neuro-oncology program at UConn.’ -Dr. As a promising new therapy for certain brain tumors reaches the second phase of clinical trials, UConn Health will be one of the select few locations in the United States to make this treatment available to patients during the further evaluation of its safety and efficacy. |